It happened in the 6900 block of North Lee Highway near Hendricks Lane.
Emergency crews found a t-bone type collision.
THP Officials say it appears a Mustang pulled out in front of a Ford F-250 and was hit in the passenger side.
The passenger of the mustang, Misty Keppel died on the scene.
Driver Donald Massey had to be taken to the hospital, and then airlifted to a level 1 trauma center in Chattanooga.
Officials say it appears Massey was drinking.
Charges are pending.